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Phospholipidosis (intracellular phospholipid accumulation) has become affecting some tissues of mice, rats, and dogs given multiple doses of azithromycin. It has been demonstrated in a number of organ systems (e.g., eye, dorsal root ganglia, liver, gallbladder, kidney, spleen, and pancreas) in dogs given azithromycin at doses which, expressed on such basis as mg/m2, are approximately comparable to the recommended adult human dose, plus rats treated at doses approximately one-sixth of the recommended adult human dose. This effect may be shown to be reversible after cessation of azithromycin treatment.
Phospholipidosis (intracellular phospholipid accumulation) may be observed in some tissues of mice, rats, and dogs given multiple oral doses of azithromycin. It has been demonstrated in a number of organ systems (e.g., eye, dorsal root ganglia, liver, gallbladder, kidney, spleen, and/or pancreas) in dogs and rats addressed with azithromycin at doses which, expressed judging by Horizon Healthcare body floor, resemble or under buy Zithromax online human dose. This effect has been shown to be reversible after cessation of azithromycin treatment. Based on the pharmacokinetic data, phospholipidosis may be affecting the rat (50 mg/kg/day dose) in the observed maximal plasma concentration of 1.
In many studies of intravenous azithromycin for community-acquired pneumonia, through which 2 to 5 IV doses got, the reported adverse reactions were mild to moderate in severity and were reversible upon discontinuation from the drug. The majority of patients over these trials had a number of co-morbid diseases and were receiving concomitant medications. Approximately 1.2% in the patients discontinued intravenous ZITHROMAX therapy, plus a total of 2.4% discontinued azithromycin therapy by either the intravenous or oral route due to clinical or laboratory side effects.
Zithromax is most familiar for the public as the ’Z-Pak,’ an expedient five-day pill regimen with a dose of 500 mg (2 tablets of 250 mg) day one and 250 mg to the remaining four days. But, Zithromax also comes in several dosages and forms, including oral tablets and liquids for oral use, injections and intravenous drips.